Fragment-based drug discovery a practical approach

상세정보

자료유형	단행본
서명/저자사항	Fragment-based drug discovery : a practical approach/ [edited by] Edward Zartler and Michael Shapiro.
개인저자	Zartler, Edward.  Shapiro, Michael  (Michael J.)
발행사항	Hoboken, N.J.: John Wiley & Sons, 2008.
형태사항	ix, 285 p.: ill.; 25 cm.
ISBN	9780470058138 (cloth):
서지주기	Includes bibliographical references and index.
내용주기	Introduction to fragment based drug discovery / Tim Mitchell and Mike Cherry -- Building the perfect beast : designing a fragment process to fit your needs / Edward Zartler and Michael Shapiro -- Assembling a fragment library / Mark Brewer ... [et al.] -- The practical aspects of using NMR in fragment based screening / Johan Schultz -- Application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses / William J. Metzler ... [et al.] -- Target immobilized NMR screening : validation and extension to membrane proteins / Virginie Fru◆U0308◆h, Robert J. Heetebrij and Gregg Siegal -- In situ fragment-based medicinal chemistry : screening by mass spectrometry / Sally-Ann Poulsen and Gary H. Kruppa -- Computational approaches to fragment and substructure discovery and evaluation / Eelke van der Horst and Adriaan P. IJzerman -- In silico design chapter / Bradley Feuston ... [et al.] -- Fragment-based lead discovery using covalent capture methods / Stig K. Hansen & Daniel A. Erlanson -- Identification of high affinity beta-secretase inhibitors using fragment-based lead generation / Jeffrey S. Albert and Philip D. Edwards.
일반주제명	Drug development. Drugs -- Design. Ligands (Biochemistry) Drug Design. Ligands. Magnetic Resonance Spectroscopy -- methods.
분류기호(NLMC)	QV 744 F8115 2008
분류기호(DDC)	615.19
언어	영어