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| 001 | | 000013864471 |
| 005 | | 20191104103042 |
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| 007 | | cr ||||||||||| |
| 008 | | 160324t20162016dcua sb 000 0 eng d |
| 020 | |
▼a 9780309388719
▼q electronic bk. |
| 020 | |
▼a 0309388716
▼q electronic bk. |
| 020 | |
▼z 9780309388702
▼q paperback |
| 020 | |
▼z 0309388708
▼q paperback |
| 035 | |
▼a 1179498
▼b (N$T) |
| 035 | |
▼a (OCoLC)945556529 |
| 040 | |
▼a MMU
▼b eng
▼c MMU
▼d 224010
▼d N$T
▼e rda |
| 043 | |
▼a n-us--- |
| 050 | 4 |
▼a RG133.5 |
| 060 | 4 |
▼a WQ 208 |
| 072 | 7 |
▼a HEA
▼x 039000
▼2 bisacsh |
| 072 | 7 |
▼a MED
▼x 014000
▼2 bisacsh |
| 072 | 7 |
▼a MED
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▼a MED
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▼a MED
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| 082 | 04 |
▼a 616.692
▼2 22 |
| 090 | |
▼a 616.692 |
| 110 | 2 |
▼a Institute of Medicine (U.S.).
▼b Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Maternal Transmission of Mitochondrial DNA Diseases,
▼e author. |
| 245 | 10 |
▼a Mitochondrial replacement techniques
▼h [electronic resource]:
▼b ethical, social, and policy considerations /
▼c Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Maternal Transmission of Mitochondrial DNA Diseases, Board on Health Sciences Policy, Institute of Medicine ; Anne Claiborne, Rebecca English, and Jeffrey Kahn, editors ; National Academies of Sciences, Engineering, Medicine. |
| 260 | |
▼a Washington, D.C.:
▼b National Academies Press,
▼c [2016]. |
| 300 | |
▼a 1 online resource (xvi, 184 pages) :
▼b color illustrations. |
| 336 | |
▼a text
▼b txt
▼2 rdacontent |
| 337 | |
▼a still image
▼b sti
▼2 rdacontent |
| 338 | |
▼a online resource
▼b cr
▼2 rdacarrier |
| 504 | |
▼a Includes bibliographical references. |
| 505 | 0 |
▼a Introduction -- Science and policy context -- Do ethical, social, and policy considerations preclude MRT? -- Regulation and oversight of MRT in humans. |
| 520 | |
▼a "Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the technique raises significant ethical and social issues. It would create offspring who have genetic material from two women, something never sanctioned in humans, and would create mitochondrial changes that could be heritable (in female offspring), and therefore passed on in perpetuity. The manipulation would be performed on eggs or embryos, would affect every cell of the resulting individual, and once carried out this genetic manipulation is not reversible. Mitochondrial Replacement Techniques considers the implications of manipulating mitochondrial content both in children born to women as a result of participating in these studies and in descendants of any female offspring. This study examines the ethical and social issues related to MRTs, outlines principles that would provide a framework and foundation for oversight of MRTs, and develops recommendations to inform the Food and Drug Administration's consideration of investigational new drug applications"--Publisher's description. |
| 650 | 0 |
▼a Reproductive technology
▼x Moral and ethical aspects
▼z United States. |
| 650 | 0 |
▼a Reproductive technology
▼x Government policy
▼z United States. |
| 650 | 0 |
▼a Mitochondrial DNA
▼x Abnormalities
▼z United States. |
| 650 | 0 |
▼a Mitochondrial pathology
▼z United States. |
| 650 | 0 |
▼a Medical ethics
▼z United States. |
| 650 | 12 |
▼a Mitochondrial Replacement Therapy
▼x ethics. |
| 650 | 12 |
▼a Mitochondrial Replacement Therapy
▼x standards. |
| 650 | 22 |
▼a Mitochondrial Diseases
▼x prevention & control. |
| 650 | 22 |
▼a Reproductive Techniques, Assisted
▼x ethics. |
| 650 | 22 |
▼a Government Regulation. |
| 650 | 22 |
▼a Ethics, Medical. |
| 650 | 7 |
▼a HEALTH & FITNESS / Diseases / General
▼2 bisacsh |
| 650 | 7 |
▼a MEDICAL / Clinical Medicine
▼2 bisacsh |
| 650 | 7 |
▼a MEDICAL / Diseases
▼2 bisacsh |
| 650 | 7 |
▼a MEDICAL / Evidence-Based Medicine
▼2 bisacsh |
| 650 | 7 |
▼a MEDICAL / Internal Medicine
▼2 bisacsh |
| 651 | 2 |
▼a United States. |
| 655 | 4 |
▼a Electronic books. |
| 700 | 1 |
▼a Claiborne, Anne B.,
▼e editor. |
| 700 | 1 |
▼a English, Rebecca A.,
▼e editor. |
| 700 | 1 |
▼a Kahn, Jeffrey P.,
▼e editor. |
| 776 | 08 |
▼i Print version:
▼t Mitochondrial replacement techniques.
▼d Washington, D.C. : National Academies Press, 2016
▼z 9780309388702
▼w (OCoLC)933521007 |
| 856 | 41 |
▼u https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=1179498 |